终末期肝病模型在肝病中的应用进展

Model for end-stage liver disease and its applications in liver disease

终末期肝病模型(modelforend_stageliverdisease,MELD)是主要应用血清胆红素、凝血酶原时间国际标准化比值和血清肌酐指标来评价的系统。其在预测终末期肝病死亡率及肝移植中的应用已渐趋成熟,应用范围也开始扩大到重型肝炎、肝癌中。部分学者针对腹水等严重的肝病并发症对MELD评分的影响做了相应研究,并对血钠浓度在预测肝病患者死亡率中的作用作了进一步的研究。文中对MELD作了回顾,并对最新进展进行阐述。

MELD score includes total of serum bilirubin, international normalized ratio （INR）, creatinine. The score system is exact to predict the mortality of chronic hepatitis and widely used pre-transplantation, Now it is applied to assess the severity of severe hepatitis and hepatocellular carcinoma. Because of the important prediction of the mortality, scientists used the concentration of sodium to represent the severe complications of ascites. Many studies are still going on and maybe the score system will be more efficient with some modifications.