摘要
The binding kinetics properties of three Ru（Ⅱ） complexes of [Ru（bpy） 2（dhipH 3）]（ClO4）2, [（bpy） 2Ru（eipcH）]（ClO4）2 and [（bpy） 2Ru（ebipcH 2）Ru（bpy） 2]（ClO4）4, where bpy2,2′-bipyridine, dhipH 33,4-dihydroxyphenyl-（imidazo[4,5-f][1,10]phenanthroline）, eipcHN-ethyl-4-（imidazolo[4,5-f]-（1,10-phenanthrolin）-2-yl）carbazole, and ebipcH 2N-ethyl-4,7-bis（imidazolo[4,5-f]-（1,10-phenanthrolin）-2-yl）carbazole, with yeast-RNA were investigated by monitoring the decays in absorbance for π-π* absorption peaks at 286 nm with binding time. The decay curves for the complexes were well fitting to biexponential decay functions with half-life times for rapidly-decayed components being 0.006, 0.02 and 0.8 min, and those for slowly-decayed components being 0.7, 4.2 and 103 min, respectively. The rapidly- and slowly-decayed components are probably due to electrostatic interaction and aromatic base stacking of the RNA with the Ru（Ⅱ） complexes, respectively. The results indicate that not only binuclear complexes but also mononuclear complexes can slowly bind to the RNA depending on the molecular structures of the complexes.
The binding kinetics properties of three Ru （ Ⅱ ） complexes of [ Ru （ bpy ） 2 （ dhipH3 ） ] （ ClO4 ） 2,[ （bpy） 2 Ru （ eipcH ） ] （ ClO4 ） 2 and [ （ bpy ） 2 Ru （ ebipcH2 ） Ru （ bpy ） 2 ] （ ClO4 ） 4, where bpy = 2,2＇-bipyridine, dhipH3 = 3,4-dihydroxyphenyl- （ imidazo [ 4,5 -f] [ 1,10 ] phenanthroline ）, eipcH = N-ethyl-4- （ imidazolo [ 4,5-f] - （ 1,10-phenanthrolin ） -2-yl ） carbazole, and ebipcH2 = N-ethyl-4,7-bis （ imidazolo [ 4,5-f] - （ 1,10-phenanthrolin）-2-yl） carbazole, with yeast-RNA were investigated by monitoring the decays in absorbance for π-π^＊ absorption peaks at 286 nm with binding time. The decay curves for the complexes were well fitting to biexponential decay functions with half-life times for rapidly-decayed components being 0. 006, 0. 02 and 0. 8 min, and those for slowly-decayed components being 0. 7, 4. 2 and 103 min, respectively. The rapidly- and slowly-decayed components are probably due to electrostatic interaction and aromatic base stacking of the RNA with the Ru （ Ⅱ ） complexes, respectively. The results indicate that not only binuclear complexes but also mononuclear complexes can slowly bind to the RNA depending on the molecular structures of the complexes.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2006年第3期559-561,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20371008和90401007)
北京师范大学本科生科学研究基金资助.
