病理性瘢痕中丙二醛含量的测定

Determination of the Contents of Malondialdehyde in Pathological Scar Tissues

目的:了解病理性瘢痕中脂质过氧化水平的变化。方法:应用化学比色法测定正常人皮肤(8例)、增生性瘢痕(10例)、瘢痕疙瘩(10例)及成熟瘢痕(7例)组织中丙二醛的含量。结果:与正常人皮肤比较,增生性瘢痕和瘢痕疙瘩中丙二醛含量明显升高(P<0·05),成熟瘢痕与正常人皮肤比较无差异(P>0·05);与成熟瘢痕比较,增生性瘢痕和瘢痕疙瘩中MDA含量非常显著升高(P<0·01);增生性瘢痕和瘢痕疙瘩比较无差异(P>0·05)。结论:病理性瘢痕中自由基含量增加引起脂质过氧化程度加重,瘢痕过度增生可能与此有关。

Objective： To investigate the change of lipopemxidation in pathological scar tissues. Methods： The content of malondialdehyde was detected by spectrophotometric method in the following fiscues： hpertrohic scar （ 10 cases）, keloid （ 10 cases） and mature scar （7 cases） and normal skin （8 cases）, which was used as control.Results： The contents of malondialdehyde in hypertrophic scar and keloid were increased significantly in comparison with the normal skin and mature scar （ P 〈 0.05）. The difference between the mature scar and normal skin was not significant （ P 〉 0.05 ） . Conclusion： The level of lipopemxidafion was eleuated because of the accumulation of free radicals in pathological scar tissues, which probably causes hyperplasia of scar tissues.