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盐酸罗哌卡因及有关物质的HPLC测定 被引量：2

Determination of Ropivacaine Hydrochloride and Its Related Substances by HPLC
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摘要 建立了HPLC法测定盐酸罗哌卡因含量及有关物质。采用C8柱,流动相为乙腈-0.015mol/L磷酸二氢钾溶液(25∶75),检测波长263nm。在1.28～1280μg/ml范围内线性关系良好,盐酸罗哌卡因和两个有关物质的检测限分别为7.0、6.0和6.0ng。平均回收率为100%,RSD为0.29%。 A HPLC method for determination of ropivacaine hydrochloride and its related substances was established. A C8 column was used with the mobile phase of acetonitrile -0.015mol/L potassium dihydrogen phosphate solution （25 ： 75） at the detection wavelength of 263nm. The calibration curve was linear in the range of 1.28 - 1280~tg/ml. The detection limit of ropivacaine hydrochloride and its two related substances were 7.0, 6.0 and 6.0ng, respectively. The average recovery was 100% with RSD of 0.29%.
作者 冯乙巳 杨庆华 黄庆云 孙立云 姚日生
机构地区 合肥工业大学化工学院制药工程系 安徽科隆药物研究所
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2006年第3期189-191,共3页 Chinese Journal of Pharmaceuticals
关键词 盐酸罗哌卡因 有关物质 高效液相色谱 测定 ropivacaine hydrochloride related substance HPLC determination
分类号 TQ460.72 [医药卫生—药物分析学] O657.72 [理学—分析化学]
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中国医药工业杂志
2006年 第3期

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