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肽类药物的口服吸收促进剂氯化N-三甲基壳聚糖 被引量：4

Recent Development of N-trimethyl Chitosan Chloride as an Absorption Enhancer of Oral Peptide Drugs
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摘要 对氯化N-三甲基壳聚糖的制备、理化性质、促吸收机制、细胞毒性评价及制剂等方面作一综述。氯化N-三甲基壳聚糖是壳聚糖的部分季铵化衍生物,能溶于中性及碱性环境中,可作为肽类药物的口服吸收促进剂。 The synthesis, physico-chemical properties, absorption enhancing properties, cytotoxic evaluation and solid oral dosage forms of N-trimethyl chitosan chloride were summarized. N-trimethyl chitosan chloride, a partially quatemised derivative of chitosan, which is soluble in neutral and basic environment, can be used as an absorption enhancer of oral peptide chugs.
作者 仲晖 张钧寿 高忠明
机构地区 中国药科大学药剂教研室 浙江新昌制药厂
出处 《药学进展》 CAS 2006年第2期75-80,共6页 Progress in Pharmaceutical Sciences
关键词 壳聚糖 氯化N-三甲基壳聚糖 吸收促进剂 肽类药物 Chitosan N-trimethyl chitosan chloride Absorption enhancer Peptide drugs
分类号 TQ464.1 [化学工程—制药化工]
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参考文献22

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二级参考文献10

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药学进展
2006年 第2期

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