高原环境因素与自由基反应

The Relationship Between Free Radical Reactions and Environmental Factors in High Altitude Area

高原环境是一个特殊的生态环境系统,其复杂多变的自然地理条件使移居和新进高原环境的人群或生物出现高原反应或发生“高原(山)病”。大气压低、氧分压低、太阳辐射强所导致的氧化应激反应是高原反应或高原病的主要原因之一。本文从高原气候因素与自由基反应,不同海拔高度对不同民族人群自由基反应的影响,相同海拔高度不同人群的自由基反应,海拔高度与机体抗氧化营养物质变化的关系,不同海拔高度紫外线强度与自由基反应及高原环境地球化学异常与自由基反应等6个方面,论述了高原环境因素与不同人群自由基反应的关系,不仅对探讨环境应激反应所产生的自由基反应与世居高原地区人群起源和进化有重要意义,而且对研究移居人群高原反应和高原病的预防、治疗及经济、国防建设具有现实应用价值。

High altitude area is a special eco-environmental system. The complex and changeful geographical conditions in high altitude area make the new migrations of human or animals affected by Mountain Sickness. The oxidative stress reaction induced by low of atmospheric and oxygen pressure and strong sun radiation is one of main causes of Mountain Sickness. In this paper, the relationships between different environmental factors in high altitude area and free radical reactions has been discussed in 6 areas. First, the results show that free radical reaction have significant negative relationship with atmospheric air pressure and oxygen pressure. Second, the native people in plateau can also be affected by free radical reaction as well as the new comer. Third, the native people in plateau can get an inherit adaptability. Forth, the inner nutrition materials can resist free radical reaction. Fifth, people exposure to high UV radiation would be easily affected by free radical reaction. Sixth, Low selenium and iodine in environment is also risk factors for people affected by free radical reaction. This study is not only of an im- portant significance in understanding the free radical reactions induced by environment stress as well as the origin and evolution of native people, but also is practically valuable for studying the Mountain Sickness of crowds immigrating to high altitude areas as well as the sickness prevention and treatment. In addition, this study is valuable for the economic development and national defense construction in high altitude area. This study may provide valuable references for studying the regulatory effects of environmental factors on Mountain Sickness and their physiology in the Western Development of China.