由mdr_1基因引起的MDR表型的逆转

The development of MDR mediated by mdr_1 gene and the reversal

多药耐药(M DR)是肿瘤治疗失败的主要原因,而肿瘤细胞多药耐药基因(m dr1)编码的细胞膜糖蛋白P170的过度表达是最常见的发生机制.论述了M DR表型在蛋白质和基因水平逆转的研究进展情况,蛋白质水平的逆转过程通过寻找合适的P-gp抑制剂来实现.目前正在进行以traiq-u idar为代表的第3代抑制剂的研究,基因水平的逆转根据机理不同,可分为反义RNA、反义寡核苷酸、核酸和RNA i等4种技术,其中RNA干扰技术是目前逆转肿瘤M DR现象的最新技术,它具有高效性、高特异性和快速性等特点,该技术正在为肿瘤的化疗开创新的前景.

Multidrug resistance （MDR） is the main reason of curing turnout - failed, and its common mechanism is cell membrane glycoprotein P170 overexpression that is coded by the turnout cell mdr1. Discusses that investigated progression of reversion of MDR in protein level and gene level. Apposite P - gp inhibitor can achieve reversion in protein level. Now traiquidar is stuied as the third inhibitor. Reversion mechanisms of gene level are different, such as antisense RNA, antisense oligonudeotide, nucleic acid and RNAi, and RNAi is the most new technique that is used in MDR -reversed. This technique has some characteristics, such as high effect, high specificity and tacho, and it starts new oudook of neoplastic cure.