青少年心脏瓣膜退行性变

Heart Valve Degeneration in Teen-Agers

目的：青少年心脏瓣膜退行性变是一种独特的疾病。研究它的发病机制、临床特点和病理变化有重要意义。方法：１９８３年１月至１９９３年１２月，对５３５例心脏瓣膜病患者行心脏瓣膜替换术。结果：２３例１９岁以下患者经手术和病理证实为瓣膜粘液样退行性变，占同期瓣膜替换手术病例的４．２９％。结论：青少年心脏瓣膜退行性变是一组临床特点鲜明、病理改变独特的疾病，其发病机制尚不明确，心脏胶原纤维代谢异常可能是原发缺陷。

Objective:Heart valve degeneration in teen-agers is an unique disease entity. It is important to study the clinical characteristics, pathological changes and pathogenesis of this disease.Methods:From January 1983 to December 1993,535 patients were treated by valve replacement.Result:Among the 535 cases,23 aged less than 19 years were found to have valvular myxomatous de generation(4.92%).Conclusion:Myxomatous valve in teen-agers is a disease entity with prominent clinical characteristics and distinctive pathological changes.So far the cause of the disease is unknown. Collagen dissolution may be the primary defect.The operative methods are still under investigation.