摘要
研究了以4-氯苯甲醛(PCAD)和无水氟化钾为原料合成4-氟苯甲醛(PFAD)的氟化反应。在溶剂选择,催化剂筛选、工艺条件优化以及动力学研究等方面进行了研究,在以硝基苯为溶剂N(KF):N(PCAD):N(PH4Pr):N((?))=3: 1:0．1:0．05,反应温度为210℃,反应时间8小时,最佳工艺条件下,4-氟苯甲醛的收率达80．9％,纯度99．5％以上。
The fluorination of 4-chlorobenzaldehyde was studied in solvents using anhydrous KF as the fluorinating agent. The selection of solvents, catalyst screening, process optimizing and reaction kineeties were discussed. Under the optimum reaction conditions ofn（KF）：n （PCAD）：n（Ph4PBr）：n（Cat.A）=3：1：0.1：0.05, reaction temperature 210℃, reaction time 8h and nitrobenzene as solvent, the yield of 4- fluorobenzaldehydc was 〉 80.9% and the purity was 〉 99.5%.
出处
《染料与染色》
CAS
2006年第1期25-27,24,共4页
Dyestuffs and Coloration
基金
江苏省科技攻关项目项目编号(BE2004045)
关键词
4-氟苯甲醛
4-氟苯甲醛
相转移催化
4-Chlorobenzaldehyde
4-Fluorobenzaldehyde
halogen-exchange
fluorination phase transfer catalysis, anti-dehalogenating agent
