胸腺肽治疗对复发性生殖器疱疹患者T细胞亚群的影响

The influence of the treatment of thymus peptide on the T-cell subsets in patients with recurrent genital herpes

目的探讨胸腺肽治疗对复发性生殖器疱疹(RGH)患者T细胞亚群的影响。方法50例RGH患者随机分为2组:治疗组28例,对照组22例。对照组口服阿昔洛韦片治疗;治疗组除口服阿昔洛韦片外,还接受胸腺肽注射液治疗。另设30名健康体检者为正常对照组。所有患者在治疗前后均采用流式细胞仪检测T细胞亚群。结果(1)RGH组与正常对照组比较,CD4+T细胞数及CD4+/CD8+比值均明显下降(P<0.001),CD8+T细胞数升高(P<0.01)。(2)治疗组治疗后CD4+T细胞数及CD4+/CD8+比值均明显升高,CD8+T细胞数明显下降,与治疗前及对照组相比差异均具有显著的统计学意义(P均<0.05)。(3)经胸腺肽治疗后RGH复发频率明显下降,与对照组相比差异有显著的统计学意义(P<0.001)。结论RGH患者存在细胞免疫功能异常,细胞免疫在RGH的发病中起重要作用。胸腺肽对其具有调节作用,治疗RGH可获得较好疗效。

Objective To explore the influence of the treatment of thymus peptide on the T-cell subsets in patients with recurrent genital herpes（RGH）. Methods 50 patients with RGH were randomly divided into two groups. The treatment group was treated with thymus peptide. The T-cell subgroups in all patients were determined by flow cytometry before and after tretment. Results 1 ） The CD4^＋ T-cells and the CD4^＋/CD8^＋ ratio in RGH patients were obviously lower and the CD8^＋ T-cells were obviously higher compared with the normal controls （all P 〈 0.01 ） ; 2 ） The CD4 ＋ T-cells and the CD4^＋/CD8^＋ ratio were increased markedly and the CD8^＋ T-cells were decreased markedly in patients of the treatment group after treatment compared with those before treatment and the controls（all P 〈 0.05）. 3）The frequency of relapse of RGH in the patients treated with thymus peptide was significantly decreased compared with the controls （P 〈 0.001 ） .Conclusions The cellular immunity is abnormal in RGH patients and it plays an important role in pathogenesis of RGH.Thymus peptide may enhance cellular immunity of the patients and these patients treated with it showed some better effects.