大鼠听觉事件相关电位的反应特性

Responsibility of auditory event-related potential in rats

目的探讨被动模式下大鼠是否存在听觉事件相关电位(auditoryevent-relatedpotential,AERP及其反应特点,建立测试动物AERP的方法。方法选择正常幼年和成年大鼠为测试对象,麻醉状态下以被动模式进行AERP的测试。比较二组AERP的反应特点,并与被动模式记录的人的AERP进行比较。结果应用被动模式可测出大鼠的AERP。虽幼年鼠的潜伏期和幅值分别略长于和低于成年鼠,但在统计学上无显著性意义。大鼠AERP的波形与人基本上相似,但反应性和稳定性不如人类。结论大鼠存在着与人类相似的AERP波形,并随年龄有一个发育、分化和成熟的过程,这一过程的完成可能较早。大鼠可作为研究AERP神经生理机制的实验动物。

OBJECTIVE To explore whether auditory event-related potential （AERP） exists in rat and what its features are, and to set up a set of AERP recording technique. METHODS Ten normal juvenile and 10 adult rats were served as subjects. Each rat was anesthetized and recorded AERP with passive mode. The responsibility of AERPs between juvenile and adult rats was compared. Also, the responsibility of AERP between rats and normal humans was compared. RESULTS AERPs could be evoked with passive recording mode in rats. Although the latencies and amplitudes of juvenile rats were respectively shorter and lower than thoses of adult rats, there were no significance in statistics. The AERP waveform of rats was similar to that of humans essentially. However, compared to the humans, the responsibility and stability of AERP in rats were less satisfied. CONCLUSION A similar AERP exists in rat and human. AERP has a process of development, differentiation and maturation, which may accomplish in early age in rat. Rat can serve as the candidate animal for AERP research.