摘要
色素是血吸虫摄入宿主红细胞后的代谢产物,宿主感染血吸虫后肝中色素沉积有一定规律性,首先沉积在肝窦内,然后分别在虫卵肉芽肿的外侧和内侧,最后沉积在虫卵周围,沉积的量与肝纤维化程度呈正比(P<0·01)。经吡喹酮治疗后色素沉积量明显减少、虫卵肉芽肿减小(P均<0·01)。根据肝细胞色素沉积特点及量的变化,可判断血吸虫病小鼠肝纤维化进程以及评判吡喹酮治疗效果。
Pigment is a kind of metabolite excreted by schistosome after erythrocyte ingestion. It deposited first in liver sinusoid, then outside and inside of granuloma, and around eggs. The level of pigment was in parallel with the degree of liver fibrosis（ P 〈 0. 01）. After chemotherapy with praziquantel, the level of pigment decreased considerably（ P 〈 0. 01） and the size of granuloma shrinked obviously too（P 〈0. 01）. Therefore, the degree of liver fibrosis in mice with schistosome infection and the effect of praziquantel can be recognized by the level and distribution of pigment.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2006年第1期79-80,共2页
Chinese Journal of Parasitology and Parasitic Diseases
关键词
血吸虫病
肝纤维化
色素
Schistosoma japonicum
Liver fibrosis
Pigment
