非类固醇性抗炎药与Alzheimer病

Nonsteroidal Antinflammatory Drug and Alzheimer Disease

在阿尔茨海默病(AD)的发病机制中,神经炎症可能是神经元损伤的一个原因。流行病学证据提示,长期服用非类固醇性抗炎药(NSAID)可能对AD有保护作用,减低AD发病率和发生AD的危险。实验研究发现,NSAID的作用除了COX机制外,还可能涉及非COX机制。但是,大规模的临床随机双盲对照试验尚未证实NSAID对AD的治疗作用。本文就NSAID对AD保护机制的实验研究、流行病学研究和临床试验作一综述。

Neuroinflammation is one of the causes of neuronal injury in the pathogenesis of Alzheimer＇s disease （AD）. Epidemiological studies suggest that nonsteroidal anti-inflammatory drugs （NSAID） reduce the risk of AD. Laboratory evidence indicates that the protection of NSAID is mediated by inhibition of cyclooxygenase （COX） activity and the non-COX mechanisms. However, there is not yet any strong evidence from large randomized controlled clinical trials that NSAID is beneficial in treatment to AD. This review summarizes the experimental, epidemiological and clinical studies concerning NSAID and AD.