摘要
目的:探讨乳腺癌钼靶X线表现与c-erbB-2癌基因表达之间的相关性。方法:将165例乳腺癌患者X线征象中钙化、边缘浸润、病变密度、是否同时合并乳腺囊性增生症与经免疫组织化学染色测定c-erbB-2基因的表达状态进行对照研究。结果:165例乳腺癌患者中,有钙化者84例,占50.91%;80例有边缘浸润,占48.40%;病变区表现为高密度87例,占52.73%;乳腺癌同时合并乳腺囊性增生症85例,占51.52%。95例c-erbB-2基因表达阳性,占57.58%。结论:乳腺癌钼靶X线征象在一定程度上反映了c-erbB-2表达状态,X线表现为钙化、边缘浸润、病变区为高密度及乳腺癌同时合并乳腺囊性增生症的乳腺癌患者c-erbB-2基因表达阳性可能性更高。
Objective： To study the correlation between mammographic features and c-erbB-2 in breast cancer. Methods：The mammographic features of 165 patients with breast cancer,including calcification,infiltrated rims and density of the lesions as well as cystic hyperplasia were studied correlatively with their c-erbB-2 gene expression stained with immunohistochemical techniques. Results： In our series of 165 cases, calcification was seen in 84 cases （50.91% ）, masses with infiltrated rims and high density in 80 （48.40%） and 87 （51.52%） cases respectively. Totally, positive c-erbB-2 expression was found in 95 of the 165 cases of breast cancer. Conclusion：Mammographic features of breast cancer,in a certain extent, reflected the status of c-erbB-2 expression. A higher positive c-erB-2 expression might probably be shown if the tumor mass consisted of some mammographic features such as calcification,infiltrated rims and high density as well as the accompany of cystic hyperplasia.
出处
《放射学实践》
2006年第3期262-265,共4页
Radiologic Practice
基金
深圳市科学技术局(200404025)
