尿8-羟基脱氧鸟苷水平与糖尿病肾病的相关性

Determination of urinary 8-hydroxy-guanine levels in diabetes mellitus and its significance in diabetic nephropathy

正常对照32例和2型糖尿病（T2DM）患者68例，毛细管电泳法测定8-羟基脱氧鸟甘（8-OHdG）。T2DM患者与正常对照组比较，24h尿8-OHdG水平明显升高（46±43，11±6）且随UAER的增加而增加（UAER（20μg／min组24h尿8-OHdG含量17±9，UAER 20-200μg／min组344-22，UAER〉200μg／min组804-51）。8-OHdG与糖尿病肾病（DN）程度呈正相关，偏回归系数1．09，95％CI 1．02～1．17，P=0．01。

To explore the levels of 24 hr urinary 8-hydroxy-guanine（8-OHdG）in diabetes mellitus and its association with diabetic nephropathy（DN）. In 32 healthy subjects and 68 type 2 diabetic patients, 8-OHdG was measured with high performance capillary electrophoresis. Urinary 8-OHdG levels were significantly higher in type 2 diabetic patients and increased with increment of urinary albumin excretion rate. The levels of 24 hr urinary 8-OHdG can evaluate the systemic oxidative stress, and the degree of 8-OHdG is correlated with the degree of DN.