摘要
目的探讨冠心病患者氧化低密度脂蛋白(ox-LDL)变化与冠状动脉(冠脉)内皮损伤及相关临床表现的关系。方法54例冠心病患者均经冠脉造影证实有明显冠脉狭窄,测定其冠状窦和外周血中ox-LDL、一氧化氮(NO)及循环内皮细胞(CEC)数量,分为不稳定型心绞痛(UA)组和稳定型心绞痛(SA)组,比较两组与正常对照组(20例)间相同和不同部位之间指标的差异。结果UA组、SA组患者冠状窦血中NO含量较对照组明显降低,ox-LDL和CEC均明显增高。冠状窦血中NO含量均明显低于外周血,ox-LDL和CEC均明显高于外周血。对照组冠状窦与外周血相比三项指标均未见明显差别。结论冠心病患者冠脉局部ox-LDL升高与冠脉内皮损伤相关,并与冠心病病情严重程度一致,可能参与了冠心病病情恶化以及急性冠脉事件的发生。
Objective To investigate the role of oxidized LDL and coronary endothelial dysfunction in the development and progress of coronary heart disease （CHD）. Methods 29 patients with unstable angina （UA）, 25 patients with stable angina （SA） and 20 patients without coronary heart disease （control） were studied.Oxidized low-density lipoprotein （ox-LDL）, Nitric oxide （NO）, and circulating endothelial cells （CEC） were measured in both coronary sinus and peripheral blood during percutaneous coronary intervention （PCI）. Results The level of NO in coronary sinus in patients with CHD was lower,while the level of ox-LDL and CEC was markedly higher than those in the control group. In CHD patients, the level of NO in coronary sinus blood was lower, while the level of ox-LDL and CEC was higher than that in peripheral blood. It was no siginificant difference between coronary sinus and peripheral blood was observed in the control group. Conclusion Oxidized LDL not only plays an important role in coronary endothelial dysfunction , but also contributes to the progress in the comornary heart disease. It may be one of the pathophysiological basis of acute coronary incidents.
出处
《中国介入心脏病学杂志》
2006年第1期18-21,共4页
Chinese Journal of Interventional Cardiology
基金
国家自然科学基金项目(30470729)
