支气管哮喘与一氧化氮及cGMP关系的初步研究

Preliminary approach on relation of childhood asthma with nitric oxide (NO) and cGMP

研究目的小儿哮喘时一氧化氮的作用机制及临床意义。研究方法哮喘患儿３３例，正常健康儿童２０例为对照组。测定一氧化氮（ＮＯ）水平及ｃＧＭＰ水平，并对测定结果进行统计学分析。研究结果所有哮喘患儿血浆ＮＯ及ｃＧＭＰ水平在治疗前均明显高于正常儿童（Ｐ均＜０．００１），其中９例重度哮喘患儿血浆ＮＯ水平较２４例轻中度哮喘患儿更高（Ｐ＜０．００１）；治疗后血浆ＮＯ及ｃＧＭＰ水平均恢复正常。结论哮喘发作时一氧化氮产生过多，发挥其细胞及组织毒性作用，使肺上皮细胞等损伤，从而引起和加重哮喘发病，且血浆ＮＯ水平与哮喘病情密切相关。

Objectives To search for the potential role of no in the patho-genesis of asthma and its clinical significance.Methods Thirty-three patients with asthma and 20 healthy controls were envolved. NO and cGMP levels were examined. The results were analysed statistically.Results The results showed that before therapy all asthmatic children had increased amounts of NO,cGMP than normal control subjects (P<0.001). In which the 9 severe asthmatic children (status asthmaticus) had increased amounts of NO than the 24 mild asthmatic children. After therapy, there was not any significant alteration in the levels of no, cGMP in the asthmatic children and the normal subjects (P>0.05).Conclusions The results suggests that increased production of NO in asthmatic children, and the NO produced could cause cytotoxicity and mediate pulmonary epithelial cells damage associated with asthma. Plasma levels of NO may be useful in forecasting the severity of illness.