爱维治治疗前部缺血性视神经病变的疗效观察

Therapeutic effect of ai-weizhi on anterior ischmic optic neuropathy

目的观察爱维治治疗前部缺血性视神经病变(AION)的疗效。方法临床确诊的AION患者58例60只眼,其中29例30只眼接受爱维治1200mg/d静脉滴注治疗(治疗组);另外29例30只眼接受1～2种溶栓抗凝剂或血管扩张剂1次/d静脉滴注治疗(对照组)。均以15d为1个疗程。对照组中20只眼还同时进行眼局部药物注射,包括糖皮质激素、654-2球后或球旁注射,1次/d或1次/2d,用药3～5次。两组患者用药后每天观察视力、眼底变化,治疗前有视野检查者复查视野。结果治疗组视力提高程度明显好于对照组,两组间差异有统计学意义(t=2.74,P<0.01);用药第3天,两组视力提高程度差异无统计学意义(t=1.34,P>0.05);第5、10、15天,治疗组视力提高程度明显好于对照组,其差异有统计学意义(t=2.01,P<0.05;t=2.07,P<0.05;t=2.74,P<0.01);治疗组有视野检查的15只眼中,13只眼治疗后视野好转,占87.00%;2只眼无变化,占13.00%。对照组有视野检查的13只眼中,4只眼治疗后视野好转,占31.00%;9只眼无变化,占69.00%。两组视野变化的差异比较有统计学意义(χ2=9.66,P<0.01)。结论爱维治治疗AION有效。

Objective To observe the therapeutic effect of ai-weizhi on anterior ischmic optic neuropathy （AION）. Methods In 58 patients （60 eyes） who were diagnosed as with AION, 29 patients （30 eyes） underwent intravenous drip with ai-weizhi （1 200 mg/d） （treatment group）, and the other 29 patients （30 eyes） underwent intravenous drip with 1-2 kinds of thrombolytie coagulant or vasodilator （once per day） （control group） with the period of treatment of 15 days. In the control group, ocular local injection, including glueo-eortieosteroid and 654-2 behind or beside the eyeball injected once per day or every 2 days for 3-5 times, was perfomed on 20 eyes simultaneously. The changes of visual acuity and ocular fundus of the patients after injection were recorded, and the visual field was counterchecked in the patients who had underwent the examination before the treatment. Results The visual acuity was better in treatment group than which in control group with a significant difference （t = 2.74, P〈0. 01）. The visual acuity in treatment group didn＇t differ much from which in the control group 3 days after treatment （t= 1.34, P〈0. 05）. At the 5th, 10th and 15th day after treatment, the visual acuity was better in treatment group than which in control group with a significant difference （t = 2.01, P〈0. 05 ;t = 2.07, P〈 0. 05;t=2.74, P〈0. 01）. In 15 eyes in control group which had undergone examination of visual field, the visual field improved in 13 （87.00%） and of remained still in 2 （13.00%）. In 13 eyes in treatment group which had undergone examination of visual field, the visual field improved in 4 （31.00%） and remained still in 9 （69.00%）. There was a significant difference between the two groups （χ^2=9.66,P〈 0. 01）. Conclusion Ai-weizhi is efficacious in treatment of AION.