趋化因子与树突状细胞

Chemokines and Dendritic Cells

树突状细胞(DC)是骨髓来源的专职抗原呈递细胞。DC可引起T细胞活化和耐受从而启动和抑制免疫反应。DC居留在所有组织和器官,在活化后可移动到周围淋巴器官,呈递抗原至T区的T细胞。由于DC在T细胞活化中的中心作用,在治疗学上利用DC对免疫系统递送阳性和阴性信号引发广泛兴趣。不同成熟阶段的DC,与趋化因子之间相互作用。该综述主要描述DC与趋化因子的交互作用。

Dendritic cells（DC） are hone marrow-derived professional, antigen-presenting cells. DCs have ability to prime or tolerize T lymphocytes, thereby initiating or inhibiting immune responses. They reside in all tissues and organs,migrate to peripheral lymphoid organs to present antigen to T lymphocytes in T cell zones upon appropriate activation. Because of this central role in T cell activation,there is a great deal of interest in using DCs therapeutically to diliver positive or negative signals to immune system. DCs at different atages of maturation interact with chemokines. This review will describe the interactions between DCs and the chemokine system.