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IL-18的免疫调节功能及其应用 被引量：7

Immunoregulation and application of interleukin-18
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摘要 IL-18是一种具有多向和多层次免疫调节功能的细胞因子,其细胞来源较广。它可通过NF-κB、p56LCK-MAPK、Perforin等多个信号传导途径参与细胞凋亡以及IFN-γ分泌诱导及功能性免疫细胞活性的激活,从而直接或间接激活T细胞、NK细胞、PBMC、DC等免疫细胞的增殖、分化、抗原呈递、CTL反应等,并诱导这些细胞分泌效应性细胞因子或延长免疫保护,进而促进免疫系统增强抗感染、抗肿瘤等免疫效应。IL-18除了主要介导细胞免疫外,在一定条件下,亦能促进抗原特异性中和抗体以及Th2型细胞因子的应答。在某些疾病的防治和诊断中,具有重要临床意义。
作者 叶亦见 陈益 Charles Muleke 李祥瑞
机构地区 南京农业大学动物医学院
出处 《畜牧与兽医》 北大核心 2005年第12期54-56,共3页 Animal Husbandry & Veterinary Medicine
关键词 白介素-18 免疫调节 干扰素-Γ
分类号 S852.4 [农业科学—基础兽医学]
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参考文献24

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二级参考文献17

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畜牧与兽医
2005年 第12期

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