肝癌高发区不同饮用水类型中微囊藻毒素含量调查

StudiesonMicrocystinContentsinDifferentDrinkingWaterinHighlyEndemicAreaofLiverCancer

为了解肝脏促癌剂微囊藻毒素（ＭＣ）在肝癌高发区饮用水中的污染情况，于１９９２至１９９３年对江苏海门居民饮用水中藻类及其产生的ＭＣ进行了检测，经鉴定在海门沟河水中颤藻是目前已被证明能产生ＭＣ的最常见的藻属；在６５个水样中有２份经高效液相和液相色谱／质谱分析确定含有ＭＣ。进一步于１９９４年７月在江苏海门采集不同饮用水源共９８９份，采用高敏感度酶联免疫方法测定ＭＣ含量。结果在沟塘水、河水、浅井水和深井水中ＭＣ的阳性率（＞５０ｐｇ／ｍｌ）分别为１７．３％，３１．９％，４．３％，０．０％；阳性样本中ＭＣ平均含量分别为１０１，１６０，６８，０。在沟塘水和河水中ＭＣ的阳性率和阳性样本中的平均含量均显著大于浅井水和深井水，提示应对饮用水中ＭＣ与肝癌的关系作进一步研究。

Inordertostudythepolutionwithmicrocystin(MC),apotentlivercancerpromoter,indrinkingwatreinhighlyendemicareaoflivercancer,cyanobacteriaanditsproductMCwerede-tectedindrinkingwaterinHaimen,JiangsuProvinceduring1992to1993.Oscilatoriawasidentifiedasthemostcommonspeciesofcyanobacteriainpond-ditchandriverwaterinHaimen,JiangsuProvince,whichcanproduceMC.MCwasdetectedintwoof65watersampleswithhighperfor-manceliquidchromatography,liquidchromatographyandmassspectrography.Inaddition,studieswereconductedin989sampescolectedfromdrinkingwaterinHaimen,JiangsuProvinceandmoresensitiveELISAwasusedtodetecttheirMCcontents.ResultsshowedproportionsofsampleswithpositiveMC(greaterthan50pg/ml)were17.3%,31.9%,4.3%and0forpond-ditch,river,shal-lowanddeepwelwater,respectively,withaveragecontentsof101,160,68and0pg/ml,respec-tively.proportionsofpositiveMCsamplesandaverageMCcontentsforpond-ditchwaterweresig-nificantlygreaterthanthoseinshalowanddeepwelwater.Itsuggestsstudiesonrelationshipbe-tweenMCandlivercancershouldbeconductedfurther.