摘要
瞄准：客观地在结肠镜检查期间在结肠的痉挛上评估 TJ-68 的效果。方法：受到屏蔽结肠镜检查的 101 个病人随机被分到二个组：在 51 个题目和 saline 的 TJ-68 作为在 50 的控制。内诊镜被插入到 S 字形的冒号，然后，一个痉挛区域被识别，结肠镜的尖端从痉挛区域在大约 10 公里的距离被放。内视镜的看法在 TJ-68 答案的直接喷洒前后被记录或温暖 saline。痉挛区域的管腔内区域连续地用一个计算机图象分析器被测量并且表示了为象素计数。在曲线(AUC ) 下面的区域从象素曲线被计算。统计意义被 Wilcoxon 的测试和 Mann-Whitney U 测试估计。结果：分别地，当时，在喷洒的 TJ-68 前后的痉挛区域的吝啬的 AUC 是 29,128 和 121,943 个象素与 saline，它分别地是 31,635 个象素和 48,617 个象素。因此， AUC 显著地在与喷洒 saline (P【0.001 ) 相比喷洒的 TJ-68 以后增加了。结论：在结肠的粘膜上的 TJ-68 的直接喷洒压制了结肠的痉挛和它当反副交感神经生理的代理人被禁忌时，可能在结肠镜检查期间有用。
AIM： To objectively evaluate the effect of TJ-68 on colonic spasms during colonoscopy.
METHODS： One hundred and one patients subjected to screening colonoscopy were randomly assigned to two groups： T1-68 in 51 subjects and saline as the control in 50. The endoscope was inserted into the sigmoid colon, then a spastic region was identified and the tip of the colonoscope was positioned at a distance of about 10 mm from the spastic region. The endoscopic view was recorded before and after direct spraying of the TJ-68 solution or warm saline. The intraluminal area of the spastic region was serially measured using a computer image analyzer and expressed as pixel counts. The area under the curve （AUC） was calculated from the pixel curve. Statistical significance was assessed by Wilcoxon＇s test and Mann-Whitney U test.
RESULTS： The mean AUC of the spastic region before and after TJ-68 spraying was 29 128 and 121 943 pixels, respectively, while with saline, it was 31 635 pixels and 48 617 pixels, respectively. Thus, the AUC significantly increased after TL-68 spraying compared with the spraying of saline （P〈0.001）.
CONCLUSION： Direct spraying of TJ-68 on the colonic mucosa suppressed colonic spasm and it may be useful during colonoscopy when anticholinergic agents are contraindicated.
