应激对锌营养状况评价指标的影响

EffectsofStressonIndicesforAssessingZincNutritionStatus

为了认识近年国内外研究的一些功能指标在评价机体锌营养状况时的特异性，我们以实验大鼠为模型，观察了强迫游泳、饥饿、创伤和乙醇中毒等因素对一些锌营养状况指标的影响。实验结果显示，创伤使血浆锌显著下降，饥饿３天血浆锌明显增高。肝锌含量在创伤和饥饿条件下都出现升高趋势。乙醇中毒动物除血管紧张肽转换酶以外，红细胞超氧化物歧化酶、血浆碱性磷酸酶、甘露糖苷酶和５′－核苷酸酶活性明显降低。饥饿引起碱性磷酸酶和血管紧张肽转换酶活性下降，甘露糖苷酶活性明显升高。创伤和游泳分别导致血管紧张肽转换酶活性下降和５′－核苷酸酶活性升高。这些结果表明，用上述功能指标评价机体锌营养状况时，和用血清（浆）锌指标一样，需排除某些生理和病理因素的影响。

Toevaluatethespecificityofsomefunctionalindicesinassessmentofbodyzincnutri-tionstatus,weusedexperimentalratmodeltoobservetheefectsofsomefactors,suchasforcedswimming,starvation,traumaandalcoholintoxicationonzincthestatus.Plasmazinclevelsofratssignificantlydecreasedaftertraumaincreasedafterstarvation.Liverzinccontentshowedarisingten-dencyintraumaandstarvationrats.Activitiesofsuperoxidedismutaseinredbloodcelsandalkalinephosphatase,mannosidase,5′-nucleolidaseinplasmaofratswithalcoholintoxicationdeclinedsignifi-cantly.Starvationledtodecreasedactivitiesofalkalinephosphataseandangiotensinconvertingen-zyme,butincreasedactivitiesofmaunosidase.Traumaandforcedswimmingcouldcauseincreaseofan-giotensin-convertingenzymeactivityanddecreaseof5′-nucleotidaseactivity,respectively.Thesere-sultsindicatethatphysiologicalandpathologicalefectsshouldbeexcludedfromoftheaboveindicesasplasmazincindex,intheassessmentofbodyzincnutritionstatus.