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高同型半胱氨酸血症——神经科医师需要认真面对的一个新问题 被引量:3

Hyperhomocysteinemia
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摘要 超早期溶栓治疗,已经证明可以使许多缺血性脑卒中患者获益,但由于该病所具有的高发病率、高复发率特点,如何在发病或复发前对各种危险因素进行有效地干预和控制,越来越受到关注和重视.
作者 樊东升
出处 《继续医学教育》 2005年第9期48-49,共2页 Continuing Medical Education
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  • 1MCCULLYKS.Vascular pathology of homocystinemia:implications for the pathogenesis of atherosclerosis[J].Am J Pathol,1969,56:111-128.
  • 2FARACI FM,LENTZ SR.Hyperhomocysteinemia,oxidative stress,and cerebral vascular dysfunction[J].Stroke,2004,35:345-347.
  • 3SUHARA T,FUKUO K,YASUDA O,et al.Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways[J].Hypertension,2004,43(6):1208-1213.
  • 4HANKEY GJ,EIKELBOOM JW.Clinical usefulness of plasma homocyseine in vascular disease[J].Med J Aust,2004,181 (6):314-318.
  • 5PARNETTI L,CASO V,SNATUCCI A,et al.Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke[J].Neurol Sci,2004,25:13-17.
  • 6The Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators.Homocysteine lowering with folic acid and B vitamin in vascular disease[J].N Engl J Med,2006,354:1567-1577.
  • 7BOS MJ,VAN GOOR ML,KOUDSTAAL PJ,et al.Plasma homocysteine is a risk factor for recurrent vascular events in young patients with an ischaemic stroke or TIA[J].J Neurol,2005,252:332-337.
  • 8Ventura P,Panini R.Peroxidation indices and total antioxidant capacity in plaslma during hyperhomocysteinemia induced by methionine oral loading.Metabolism,2000,49(2):225.
  • 9Junli D,Touoaki M,Hisao I,et al.Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia.Arterioscler Thromb Vasc Biol,2000,20:2579
  • 10Jaroslaw P,Malgorzata CZ,Radoslaw W,et al.Plasma homocysteine level and the course of ischemic stroke.Acta NeurobiolExp,2003,63:127.

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