摘要
目的:探讨亚甲蓝的光动力作用及其在CPD5的PDT中是否表现出抗氧化特性。方法:采用细胞排染试验(1)对比观察了亚甲蓝和CPD5对胰癌细胞的光动力效果。(2)观察了亚甲蓝对CPD5光动力作用的影响。结果:(1)亚甲蓝的PDT效果不如CPD5。(2)CPD5浓度在(0.625～5)μg/ml范围内时,由于有亚甲蓝存在,CPD5的治疗作用下降;CPD5浓度在(0.078125～0.3125)μg/ml范围内时,亚甲蓝表现出光敏化作用。结论:(1)亚甲蓝的光动力效果不理想。(2)体外光动力过程中,未发现亚甲蓝的抗氧化性质。
Objective：properties of Methylene blue were studied during the course of PDT.Methods：1.results of PDT of Methyiene blue and CPD5 were coserved in vitro.2.effect of Methylene blue on PDT of CPD5 was researched in vitro.Results：1.kiling effect of PDT of Methylene blue was not as good as CPD5.2.when the concentration of CPD5 ranged from 0.625 to 2.5μg/ml.kiling effect of PDT of CPD5 decreased with existnce of Metnyiene blue.And when the concentration of CPD5 ranged from 0.017 8125 to 0.3125μg/ml.photo-sensitive nature of Methylene blue was appeared.Conclusion：1.photo-sensitive property of Methylene blue is not enough.2.Methylene blue had not showed anti-oxygen property during the course of PDT of CPD5.
出处
《继续医学教育》
2005年第12期48-50,共3页
Continuing Medical Education
