摘要
目的:探讨亚甲蓝的光动力作用及其在CPD5的PDT中是否表现出抗氧化特性。方法:采用细胞排染试验(1)对比观察了亚甲蓝和CPD5对胰癌细胞的光动力效果。(2)观察了亚甲蓝对CPD5光动力作用的影响。结果:(1)亚甲蓝的PDT效果不如CPD5。(2)CPD5浓度在(0.625~5)μg/ml范围内时,由于有亚甲蓝存在,CPD5的治疗作用下降;CPD5浓度在(0.078125~0.3125)μg/ml范围内时,亚甲蓝表现出光敏化作用。结论:(1)亚甲蓝的光动力效果不理想。(2)体外光动力过程中,未发现亚甲蓝的抗氧化性质。
Objective:properties of Methylene blue were studied during the course of PDT.Methods:1.results of PDT of Methyiene blue and CPD5 were coserved in vitro.2.effect of Methylene blue on PDT of CPD5 was researched in vitro.Results:1.kiling effect of PDT of Methylene blue was not as good as CPD5.2.when the concentration of CPD5 ranged from 0.625 to 2.5μg/ml.kiling effect of PDT of CPD5 decreased with existnce of Metnyiene blue.And when the concentration of CPD5 ranged from 0.017 8125 to 0.3125μg/ml.photo-sensitive nature of Methylene blue was appeared.Conclusion:1.photo-sensitive property of Methylene blue is not enough.2.Methylene blue had not showed anti-oxygen property during the course of PDT of CPD5.
出处
《继续医学教育》
2005年第12期48-50,共3页
Continuing Medical Education