摘要
目的评定谷胱甘肽(GSH)支持对老年胃癌患者围手术期氨基酸谱变化的影响。方法将42例进展期胃癌根治术患者随机分成对照组(n=13)、实验A组(n=14)和实验B组(n=15)。对照组为普通输液组; 实验A组为标准营养组,用整蛋白纤维型肠内营养混悬液;实验B组为免疫增强营养组,采用肠内营养混悬液。实验组术后第2天起给予肠内营养104.5 kJ/(kg·d),连续7天,分别测定血浆GSH和血清氨基酸浓度,观察临床转归。结果除对照组出现2例肺部感染外,其余均未发生严重并发症。与术前相比,术后第7天实验B组患者血浆 GSH浓度明显上升(P=0.035),与对照组(P=0.020)、实验A组(P=0.011)差异有显著性;同时实验B组患者血清丝氨酸(P=0.023)、精氨酸(P=0.031)、缬氨酸(P=0.018)、赖氨酸(P=0.034)和蛋氨酸(P=0.030) 均有明显升高。结论早期特殊免疫增强营养支持能有效提高GSH水平,同时显著增加体内必需氨基酸和半必需氨基酸浓度,改善机体免疫功能。
Objective To evaluate the effect of glutathione (GSH) support on the changes of perioperational serum amino acids profile in patients with gastric cancer. Methods Forty-two patients were randomly divided into control group (n = 13), group A (Nutrison, n = 14), and group B (Stresson, n = 15). The plasma GSH level and the serum amino acids profile were determined 7 days before and after enteral nutrition support [104.5 kJ/(kg. d)]. Results No serious complications were observed in all groups except 2 eases of lung infections in control group. Plasma GSH was remarkedly increased in group B after 7 days of treatment (P = 0.035, compared with the baseline), which was significantly different from control group (P = 0.020) and group A (P = 0.011). The levels of serine(P = 0.023), arginine (P = 0.031 ) ,valine (P = 0.018), lysine (P = 0.034), and methionine (P = 0.030) also increased significantly. Conclusion Early special immune-enhancing nutrition support can effectively raise the level of GSH, significantly increase the levels of essential amino acids and semi-essential amino acids, and improve the immune functions of human body.
出处
《中国临床营养杂志》
2005年第6期348-351,共4页
Chinese Journal of Clinical Nutrition
基金
上海市老年病学科中青年骨干培养基金(01YQZ07)
关键词
谷胱甘肽
氨基酸谱
胃癌
手术
免疫功能
glutathione
amino acids profile
gastric cancer
operation
immune function