摘要
①目的探讨荞麦花叶总黄酮(TFBFL)对四氯化碳(CC l4)所致肝损害的保护作用。②方法50只昆明种小鼠随机分为5组。测定各组小鼠的sALT、lALT;肝组织SOD、GSH、TG、TC;计算肝脏指数(LI);观察肝脏病理变化;并对各组指标进行比较。③结果与四氯化碳模型组比较,经TFBFL预防性治疗后,小鼠sALT、lALT和肝组织MDA、TG、TC的含量及LI均明显降低,而肝脏SOD和GSH活力显著增强(P<0.05)。通过病理学切片观察,TFBFL能明显改善肝组织的病理变化。④结论TFBFL对四氯化碳造成的小鼠急性肝损伤具有很好的保护作用。
Objective The protective effect of total flavonoids of buckwheat flowers and leaves on CCl4 - induced hepatic injury in mice was observed. Methods Fifty Kunming mice were divided into 5 groups randomly. The level of sALT, IALT,and MDA, SOD, GSH, TG, TC in liver,and LI of the mice were determined. Hepato - pathologic changes of mice were observed with light microscopy. Results Compared with model control group, the levels of sALT, IALT, liver MDA, TG, TC and LI of the mice treated with TFBFL were significantly decreased, while the activities of SOD and GSH increased gready（ P 〈 0.05）. By observation of pathological slices, TFBFL could improve hepatic pathological changes distinctly. Conclusion TFBFL could prevent CCl4 - induced haptic injury.
出处
《华北煤炭医学院学报》
2005年第5期553-554,共2页
Journal of North China Coal Medical College
关键词
肝损害
荞麦
总黄酮
四氯化碳
Buckwheat
Total flavonoids
Carbon tetrachloride
Hepatic injury
