膀胱腔内灌注化疗对膀胱癌组织中P-糖蛋白表达的影响

Impact of Receiw Intravesical Chemotherapy on the Expression of P-gp in Bladder Cancer

目的：探讨膀胱癌P-糖蛋白（P—gP）的表达与临床膀胱灌注化疗之间的关系。方法：用免疫组化技术检测60例初发膀胱癌组织标本及应用膀胱腔内化疗后复发的32例活组织标本中P—gP的表达。结果：60例初发膀胱癌组织中P—gp阳性率30．5％，复发的32例中P—gp阳性率为62．5％，膀胱癌术后膀胱灌注化疗失败者的P—gP阳性率明显高于初发膀胱癌。结论：P-糖蛋白介导的多药耐药是膀胱腔内灌注化疗失败、肿瘤复发的重要原因，但P—gP表达不是引起多药耐药的唯一机制。

Objective： To explore the correlation between the expression of P -glycoprotein （P -gp） in bladder transitional cell carcinoma and the significance in cases who had received intravesical chemotherapy. Methods：The expression of P-gp in specimens of 60 cases with primary bladder transitional ceil carcinoma and 32 cases who recurrence bladder cancer were detected by immmunohistochemistry. Results：The expression of P - gp in recurrent bladder cancer was obviously higher than in primary bladder transitional ceil carcinoma（ P 〈0.01 ）o Conclusion：The P-gp- wediater MDR maybe an important cause of relapsing of bladder cancer which has been treated by chemotherapy, but P - gp expression is not the only mechanism of MDR.