腺癌细胞HLA—DR表达阳性的肺腺鳞癌

Pulmonary adenosquamocarcinoma cell carcinoma with positive HLA一DR staining of adenocarcinoma cells

作者在对肺癌间质血管进行ＨＬＡ一ＤＲ免疫组化染色时，偶然发现部分鳞癌的癌巢内明显可见到较多腺腔样结构，其腺上皮为矮立方形，圆形核，常排列成腺圈状或条索状，腺上皮细胞ＨＬＡ一ＤＲ染色为强阳性，腺腔内ＡＢ一ＰＡＳ染色全为阴性，没有分泌粘液的功能。这些特点均与Ⅱ型肺泡细胞非常一致。所以，作者认为这种腺鳞癌的腺癌部分可能来自Ⅱ型肺泡细胞。这种腺鳞癌并不少，如能将其从鳞癌中分离出来，将对肺鳞癌的治疗和预后估计会有很大帮助。

While carrying out the HLA一DR immunohistochemical staining of stromal vessels inlung cancer, we occasionally found that partial structure like glandular cavity could clearly be seen inthe cancer nests of some squamocarcinomas. The gIandular epithelium of this structure was shortcuboidal and arranged in cord shape. The nucleus was round.HLA一DR staining was strongly posi- tive. AN一PAS staining within glandular cavity was completely negative. It was shown that the struc- ture had no the function of secreting mucus,which was much similar to that of type Ⅱ alveolar cells. Therefore,we think that this kind of adenosquamocarcinoma may come from type Ⅱ alveolar ceils.In past years,itwas regarded that adenosquamocarcinoma in lung was hardly seen.Up to now,the mix-ture of adenocarcinoma and squamous cell carcinoma originated from type Ⅱ alveoltqr cells has not beenreported. In addition,we found that the proportion of adenosquamocarcinoma was not small.If it couldbe separated from squamous cell carcinoma,it would be helpful for us to treat and tIvaluate the progno-sis of patients with lung cancer.