急性白血病医院感染危险因素的非条件Logistic回归分析

A Discussion on Nosocomial Infection and its Risk Factors in Patients with Acute Leukemia

目的：探讨引起急性白血病（AL）医院感染的危险因素，为医院感染（nosocomical in fection,NI）预防措施的制定提供客观依据。方法：对我院血液科2001年10月-2003年10月住院治疗的311例AL病例进行回顾性研究，填写统一的个案登记表。其中144例为NI组，167例无任何感染者为非NI组，2组资料进行单因素F检验后，用非条件Logistic回归模型进行多元分析。结果：NI发生率为46．3％，例次发病率为51．4％，多因素分析结果筛选出年龄、糖皮质激素、外周血中性粒细胞绝对计数、化疗周期、住院天数、治疗阶段、近期感染和住院季节是NI的独立危险因素。结论：AL医院感染率高。年龄、糖皮质激素、外周血中性粒细胞绝对计数、化疗周期、住院天数、治疗阶段、近期感染和住院季节是AL医院感染的独立危险因素。

Objective：To investigate nosocomial infection risk factors in acute leukemia and provide basis for its prevention. Method.. A retrospective review of the medical records of 311 patients with acute leukemia admitted between October, 2001 and October, 2003 was performed. 144 cases were regarded as nosocomial infection group （NI group）, the other 167 cases without any infection as non NI group. The data were analyzed with the single factor X^2 test and multifactor logistic-regression analysis. Result： The incidence of nosoeomial infection was 46.30% （144/311）. The analyzed results showed that age, eortieosteroids therapy, absolute neutrophil count in peripheral blood, cycles of chemotherapy, length of hospitalization, stages of treatment, the latest infections and seasons on hospitalization were found as independent risk factors for nosoeomial infection. Conclusion. Age, eorticosteroids therapy, absolute neutrophil count in peripheral blood, cycles of chemotherapy, length of hospitalization, stages of treatment, the latest infections and seasons on hospitalization are independent risk factors for nosocomial infection in patients with acute leukemia.