摘要
目的探讨2型糖尿病与骨质疏松的关系,为糖尿病并发骨质疏松的机理研究提供基础资料。方法采用高脂饲料结合低剂量链脲佐菌素(STZ)制备2型糖尿病模型,并对骨质疏松相关指标进行测定。结果模型组动物血糖升高,对胰岛素的敏感性下降,造模成功。对骨质疏松相关指标的测定结果表明,骨钙、骨密度、骨重明显低于对照组,差别具有统计学意义,而且其下降程度与血糖的升高程度呈高度相关性。结论2型糖尿病的发生过程中也存在着骨代谢和骨转化的异常,这可能与血糖异常升高有关。
Objective： To study the relationship between type 2 diabetes and the occurrence of osteoporosis. Methods： The type 2 diabetic rats model was established by the injection of small-dose streptozotocin （STZ） combined with high-energy feeding. The indexes related to osteoporosis such as bone density, bone weights, and the contents of bone calcium were detected. Results ： The blood glucose level of model rats was significantly higher than that of normal control rata, and the sensitivity to insulin was decreased. The levels of bone calcium, bone density and bone weights of the diabetic model rats were remarkably decreased compared with those of the control rats. The results showed that there was strong negative correlation between the level of blood glucose and level of bone calcium, bone density and bone weights （the coefficient was -0. 88, -0. 71, and -0. 72 respectively）. Conclusion： The disorders in bone metabolism existed in type 2 diabetic model rats and its mechanism may be the high level of blood glucose.
出处
《陕西医学杂志》
CAS
北大核心
2006年第3期287-288,291,共3页
Shaanxi Medical Journal
