肾综合征出血热患者血清sICAM-1动态观察及临床意义

Determ ination and clincial significance of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with hemorrhagic fever with renal syndrome

目的探讨肾综合征出血热(HFRS)患者血清可溶性细胞间粘附分子-1(sICAM-1)水平的动态变化情况及其临床意义。方法用ELISA检测25例正常人和39例EHF患者四期血清sICAM-1水平。结果EHF患者血清sICAM-1水平升高,且重症组高于轻症组;少尿期及多尿期sICAM-1与血肌酐呈明显正相关,sICAM-1与外周血血小板数呈明显负相关;少尿期sICAM-1与血尿素呈明显正相关。结论血清sICAM-1作为重要的免疫分子参与HFRS的发病过程,动态检测HFRS患者血清sICAM-1水平,可作为HFRS病情观察的重要指标,同时也可为HFRS发病机制及防治研究提供线索。

Objective： To observe the change of serum levels of sICAM-1 in patients HFRS and study the clincial significance of its. Methods ：the serum levels of sICAM-1 were measured by enzyme linked immunosorbent assay （ELISA） in 39 patiants with HFRS and 25 normal people. Results compared with the control,the average serum levels of sICAM-1 were higher in patients with HFRS,furthermore the levels of those in the severe grovp were higher than in light group~ the serum concentration of sICAM-1 was positively correlated with serum levels of CRE,and was negatively correlated with the number of peripheral blood platelets in patients at oliguria and polyuria phase; the serum concentration of sICAM-1 was positively correlated with serum levels of Urea in patients at oliguria phase. Conclusion： The pilot results suggested sICAM-1 as important immunologic molecule take part in the occurrence course of HFRS, furthermore continuous measurement of those could be a important observation index and a clue to research of occurrence mechanic ,prevention and cure of HFRS.