肾综合征出血热患者血清Zn、Se含量和T淋巴细胞亚群的关系

Study on the serum Zn,Se and their relationship with T cell subsets in patients with hemorrhagec fever with syndrome

目的探讨肾综合征出血热(HFRS)中,血液锌(Zn)、硒(Se)对T淋巴细胞亚群的影响。方法对40例HFRS病人进行血清Zn、Se含量及T淋巴细胞亚群进行动态观察。结果显示HFRS病人血清Zn、Se含量在发热期明显低于正常对照组,CD4+细胞在发热期明显降低,CD8+细胞在发热期明显升高,其变化在少尿期最重,并且发现Zn、Se含量和T细胞亚群变化有一定的相关性,即Zn、Se和CD4+细胞数量正相关,和CD8+细胞数量成负相关,与CD4+/CD8+负相关。结论HFRS病人免疫功能紊乱现象与血清Zn、Se含量有关。

Objective： To study the correlation between the effects of Zn and Se with T cell subsets on pathogenesis of hemorrhagec fever with syndrome （HFRS）. Methods：Serum levels of Zn and Se, T cell subsets in 40 patients with HFRS were sequentially investigate and correlation, RESULTS：The level of serum Zn and Se in febrile phase was lower that of normoal control, the sum of CD4^＋ cell in febrile phase was significantly lower than that normal group, CD8^＋ cell was significantly higher than that of control group,and its changes must severe in oliguric phase.. The resuts also showed that there was sum correlatin existed between Zn , Se and T cell subsets. Conclusion： These findings demonsrated that irregulating of HFRS patients was correlation with Zn and Se.