摘要
痛风是由于尿酸结晶沉积在关节引起炎症、疼痛,甚至造成患者活动障碍的一组临床综合征。慢性心力衰竭患者经常伴随高尿酸血症,在这些患者中,痛风的处理是一个特殊的问题。由于心力衰竭患者对容量状态敏感和经常伴有慢性肾功能不全, 因而其痛风的治疗限制了非甾体类抗炎药和皮质类固醇激素的应用;同时,治疗高尿酸血症和痛风的药物与治疗心力衰竭的药物也存在相互影响。因此,现就慢性心力衰竭患者中高尿酸血症和痛风的处理作一综述。
Gout is a clinical syndrome resulting from the deposition of urate crystals in joints causing inflammation, intense pain, and even disability to patients, Patients with chronic heart failure frequently present with hyperuricemia. In these patients,the management of gout can be specific problems. The treatment of gout in patients with heart failure is complicated by their fragile volume state and chronic renal failure,both of which prohibit the use of non-steroidal anti-inflammatory drugs （NSAIDs} and corticosteroids. Moreover, drug interactions exist between drugs used for the treatment of hyperurieemia and gout and pharmacological agents used for the therapy of heart failure. This review therefore focuses on the treatment of hyperuricemia and gout in patients with chronic heart failure.
出处
《心血管病学进展》
CAS
2006年第2期179-182,共4页
Advances in Cardiovascular Diseases
