摘要
采用双波长分光光度系数倍率法测定尼索地平在不同浓度下在乙醇中的光解动力学参数。结果表明)当浓度低于3×10-5mol·L-1时呈表观一级反应,速率常数为1.626×10-2min-1,而高于2×10-4mol·L-1时则为零级反应,速率常数为1.238×10-6mol·L-1·min-1。此结果提示该药在生产、贮存及制剂学研究过程中,其浓度宜控制在2×10-4mol·L-1以上。
The Parameters of photodegradation kinetics of nisoldipine at different concentrations in ethanol were measured by using dual wavelength Kratio ultraviolet spectrophotometry. The results showed that the photodegradation could be described by an apparent first-order reaction if the concentration was lower than 3 × 10-5 mol.L-1,and by a zero-order reaction if the concentration was higher than 2× 10-4 mol. L-1, and the rate constants are 1. 626×10-2 min-1 and 1. 238 ×10-6 mol.L-1 .min-1 respectively. The results also showed that the concentration of the drug should be adequately controlled over 2 × 10-4 mol.L-1 in manufacture.storage, and study.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1996年第1期26-28,共3页
Chinese Journal of Pharmaceuticals
关键词
尼索地平
光解稳定性
nisoldipine, photodegradation stability