胃黏膜癌前病变大鼠舌象与胃黏膜象特点及其相关性研究

Study on the Characteristics and Relationship of Tongue Appearance and Gastric Mucosal Appearance of Rat with Gastric Mucosal Precancerous Lesions

目的探讨胃黏膜癌前病变大鼠舌象与胃黏膜象特点及其相关性。方法以Wistar大鼠造成胃黏膜癌前病变模型,从舌象肉眼观察、数码相机摄取舌象及胃黏膜象计算机分析、舌面及胃液pH值检测、舌病理及舌苔脱落细胞观察等多方面进行研究。结果对照组大鼠以淡紫舌为主,胃黏膜色泽多红润,而造模组大鼠多呈紫暗舌或有瘀斑,胃黏膜色泽多晦暗,两者符合率为82.5%。数码相机摄取舌像和胃黏膜像计算机分析两指标的红色密度值成正相关,且无论摄取的舌像还是胃黏膜像,两组比较差异均显著;造模组舌面及胃液pH较对照组升高,两组比较有统计学意义,且两指标呈正相关;舌病理检查造模组有毛细血管扩张瘀血及细胞空泡变性等改变。结论胃黏膜癌前病变大鼠舌象与胃黏膜象均具有一定的特征性,且两者具有一定的相关性。

Objective To explore the characteristics and relationship of tongue appearance and gastric mucosal appearance of rat with gastric mucosal precancerous lesions. Methods To made models with wister rats first. Results The tongue nature of rat of the control group mainly showed light purple and gastric mucosa mainly showed red, but the tongue nature of the model group mainly showed dark purple or with ecchymosis and gastric mucosa mainly showed dark red. Extemalization analysis results of the image of tongue and gastric mucosa have linear correlation. The difference of the two groups was significant in statistics, pH of the tongue surface and gastric fluid of the model group was obviously higher than that of the control group, and the two kinds of pH had also linear correlation. The pathology of the tongue of the model group was also different significantly from that of the control group. Conclusion Experimental research suggested that the tongue appearance and gastric mucosal appearance of rat with gastric mucosal precancerous lesions had their characteristics, and it had correlation between tongue appearance and gastric mucosal appearance.