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地域差异对蛋氨酸合成酶基因多态性分布的影响 被引量：2

Effect of geographical variation on distribution of methionise synthase polymorphism.
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摘要 目的比较江苏省与其他地区正常女性蛋氨酸合成酶基因的分布特点。方法采用PCR-RFLP技术对125例正常人蛋氨酸合成酶基因进行扩增及图谱分析,结合既往发表的文献进行不同地区间的比较。结果江苏省正常女性中MS基因型以A/A最多见,A/G次之。A/A基因型频率为0.576 0、A/G为0.4160、G/G为0.0080。A基因型频率为0.7840、A为0.2160。与其他地区相比较,MS基因型在江苏省正常女性中的分布与国内其它地区人群中的分布差异显著。结论蛋氨酸合成酶基因多态性在不同地区间分布存在着明显的差异。 Objective： To compare the distribution feature of Methionine Synthase gene between Jiangsu Province and other regions. Methods： The Methionise Synthase genotypes of 125 women in Jiangsu Province were determined by PCR - RFLP assay. Results ： Ms genotype frequency ： A/A 0. 5760, A/G 0. 4160, G/G 0. 0080. The genetypes frequenceies of Methionise Synthase in Jiangsu are different from those in other area in China. Conclusion： There has geographical variation in the Methionise Synthase Polymorphism in China.
作者 王素敏 石晓燕 刘晓梅 蒋涛 陈盛强 王庆霞 张伟毅 邵振堂 朱珠
机构地区 江苏省南京市妇幼保健院腔镜中心 广州医学院附属医院中心实验室 澳大利亚悉尼新南威尔士大学Liverpool医院中心实验室
出处 《中国优生与遗传杂志》 2006年第3期26-27,共2页 Chinese Journal of Birth Health & Heredity
关键词 蛋氨酸合成酶 多态性 地城差异 Methionine Synthase Polymorphism Geographical variation
分类号 R71 [医药卫生—妇产科学]
  • 相关文献

参考文献6

  • 1Friedman G,Goldschmidt N,Friedlander Y,et al.A common mutation A1298C in human methothylentrahydrofolate reductase gene:association with plasma total homocysteine and folate concentrations[J].J Nutr,1999,1(29):1656-1661.
  • 2Zhang G,Dai C.Gene polymorphism of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular disease[J].Thromb Res,2001 Nov 1,104(3):187-195.
  • 3李耀明,梁剑宁.广东汉族人蛋氨酸合成酶基因多态性[J].中国优生与遗传杂志,2004,12(4):38-39. 被引量：12
  • 4Leclerc D,Campeau E,Goyette P,et al,Human methionine synthase:cDNA cloning and identification of mutations in patients of cb/G complementation group of folate/ cobalamin disorders[J].Hum Mole Genet,1996,12:1867-1874.
  • 5Morita H,Kurihara H,Sugiyama T,et al.Polymorphism of the methionine synthase gene:association with homocysteine metabolism and late-onset vascular diseases in the Japanese population[J].Arterioscler Thromb Vasc Biol,1999 Feb,19(2):298-302.
  • 6Brown CA,McKinney KQ,Kaufman JS,et al.A common polymorphism in methionine synthase reductase increase risk of premature cornary artery disease[J].J Cardiovasc Risk,2000,7(3):197-200.

二级参考文献7

  • 1Leclerc D, Campeau E, Goyette P, et al. Human methionine synthase:cDNA cloning and identification of mutations in patients of cb/Gcomplementation group of folate/cobalamin disorders [ J ]. Hum Mole Genet, 1996,12:1867 - 1874.
  • 2van der Put NM, van der Molen EF, Kluijtmans LA, et al. Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural - tube defects and vascular disease[J]. QJM, 1997 Aug, 90(8) :511 - 7.
  • 3Lincz LF, Scorgie FE, Kerridge I, et al. Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B - cell non - Hodgkin' s lymphoma or multiple myeloma[J]. Br J Haematol, 2003 Mar, 120(6): 1051 - 4.
  • 4Morita H, Kurihara H, Sugiyama T, et al. Polymorphism of the methionine synthase gene: association with homocysteine metabolism and late - onset vascular diseases in the Japanese population[ J ]. Arterioscler Thromb Vasc Biol, 1999 Feb, 19(2) :298 - 302.
  • 5Zhang G, Dai C. Gene polymorphisms of homocysteine metabolismrelated enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases[ J ]. Thromb Res, 2001 Nov 1,104(3): 187-95.
  • 6Silaste ML, Rantala M, Sampi M. Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women[J]. J Nutr, 2001 Oct, 131 (10): 2643 -7.
  • 7Beyer K, Lao JI, Latorre P, et al. Methionine synthase polymorphism is a risk factor for Alzheimer disease[J]. Neuroreport, 2003 Jul 18, 14(10):1391-4.

共引文献11

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中国优生与遗传杂志
2006年 第3期

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