自体角膜缘上皮移植术与单纯切除治疗翼状胬肉的对比分析

Analysis of limbal epithelial antograft transplantation and simple pterygium excision in treatment of pterygium

目的对比观察自体角膜缘上皮移植术与传统的单纯翼状胬肉切除术治疗翼状胬肉的疗效。方法将41例(51只眼)翼状胬肉患者随机分成A、B组:A组21例(26只眼)行翼状胬肉切除术联合自体角膜上皮移植术;B组20例(25只眼)行传统的单纯翼状胬肉切除术。以角膜创面上皮覆盖恢复光滑透明、无新生血管和胬肉组织生长为治愈,否则视为复发。术后随访3-24个月,平均13．5个月。结果 A组2例(9．5％)失访,1 例(1只眼)翼状胬肉复发,复发率为3．84％;B组1例(5％)失访,9例(11只眼)翼状胬肉复发,复发率为 45％,两组比较,差异有非常显著意义(P<0．001)结论自体角膜缘上皮移植术治疗翼状胬肉疗效确切且能有效防止复发。

Objective To observe comparatively the effectiveness, safety, and complications of limbal epithelial antograft transplantation and simple pterygium excision in the treatment of pterygium. Methods A Total of 41 patients （51eyes） of pterygimn were dividel into 2 groups randomly ： excision of pterygimn with limbal epithelial autograft trsnsplantation surgery was taken in A group（21 cases and 26 eyes）, and simple ptergimn excision was taken in B group （20 cases and 25 eyes）. The criteria for recovery were corneal transparency with stoble epithelial healing and no ahnormal protiferation of pterygium-like tissae. The pest-operative follow - up period ranged from 3 ～24 （ 13.5 ） months. Result 2 （2 eyes） of 21 pationts in A group lost follow-up, 1 of 26 eyes（3.84% ） in A group was recurred. 1（1 eye） of 20 patients in B group lost follow-up, 11 of 25 eyes（45% ） in B group were recurred. Statistically significant difference between two group was found（ P 〈 0.001 ）. Conclusion Limbal epitelial autograft transplantation is a reasonable therapeutic mothod in the treatment of pferygium by providision a new stem cell source for an injured limbus.