乙型肝炎患者血浆纤维蛋白原的变化及临床意义

The changes of plasma fibrinogen in patients with hepatitis B and its clinic significance

目的：探讨乙型肝炎病毒所致各类型肝病患者血浆中纤维蛋白原（Fbg）水平与功能变化的临床意义。方法：将连续收治的乙型肝炎患者96例根据疾病类型分为4组：急性乙型肝炎组（40例）；亚急性重症乙型肝炎组（12例）；慢性乙型肝炎组（30例）；乙型肝炎病毒致肝硬化失代偿期（14例）；对照组（30名）为健康查体者。采用微电脑自动测定系统对其血浆Fbg水平与功能进行系列测定。结果：与对照组比较，除急性乙肝组Fbg功能指数差异无显著性意义外（P〉0．05），其余各组Fbg的各项指标：包括纤维蛋白单体聚合反应速率、最大吸光度、凝固性纤维蛋白原含量、反应迟滞时间、功能指数，差异均有显著性意义（P〈0．05～0．001）。结论：在乙型肝炎病毒所致的各类型肝病中进行纤维蛋白原系列检测，能反映患者肝功能受损时所涉及的凝血功能变化，对判断预后有帮助。

Objective：To Studey the changes of plasma concentration and function of fibrinogen in patients wih liver diseases caused by hepatitis B virus. Methods： Nine-six patients with liver diseases caused by hepatitis B virus were divided into 4 groups according to their types of liver diseases, Group Ⅰ （n= 40） suffered with acute hepatitis B; group Ⅱ （n = 12） with severe subacute hepatitis B; group Ⅲ （n =30） with chronic hepatitis B; group Ⅳ （n = 14） with decompensation hepatocirrhosis; 30 healthy peoples were taken as control group. Results： There were significant differences between the patient group and control group in the indices, such as FMPS （Fibrin monomer polymerization reaction speed）, A-max （Maximum attraction luminosity）, FC （Fibrionogen concentration）, TD （Reaction delayed time） and FI （Function index viz.FMPS/A-max） （P〈0.05～0.001） except FI of group Ⅰ .Conclusion： Hepatitis B Virus can be detected by serial measurement and analysis of fibrinogen.