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癌基因SKP2与人类恶性肿瘤 被引量：5

Oncogene SKP2 and Malignant Tumor in Human
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摘要 SKP2是新近发现的一种癌基因,是泛素连接酶(SCF)复合体的底物识别序列,对细胞周期起调控作用,与多种恶性肿瘤的发生、发展密切相关,现就SKP2与人类恶性肿瘤的关系简要综述。 SKP2,a newly found oncogene, is a recognition sequence of suhstrate for SCF complex, playing its role in regulating cell cycle and then having very close relationship with the oecurence and development of malignant tmour. Now, this article just reviews something about it.
作者 赵君 杨春鹿
机构地区 沈阳市公安医院 中国医科大学第一附属医院
出处 《医学综述》 2006年第6期325-327,共3页 Medical Recapitulate
关键词 SKP2 泛素连接酶复合体 肿瘤 Sphase kinase associated protein 2 SCF-complex Carcinoma
分类号 Q591.2 [生物学—生物化学]
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参考文献17

  • 1Zhang H,Kobayashi R,Galaktionov K, et al. p19 Skp1 and p45 Skp2 are essential dements of the cydin A-CDK2 S phase kinase[J]. Cell,1995,82(6) : 915-925.
  • 2Schulman BA, Carrano AC, Jeffrey PD, et al. Insights into SCF ubiquitin ligases from the structure of the SKP1-SKP2 complex[J]. Nature,2000,408(6810) :381-386.
  • 3Ezoe S, Matsumura I, Nakata S, et al. GATA22Pestmgen receptor chimera regulates cytokine2 dependent growth of hematopoietic calls through accumulation of p21 ( WAF1 ) and p27 ( Kipl ) proteins [J].Blood, 2002,100(10) :3512-3520.
  • 4Demetrick DJ, Zhang H, Beach D, et al. Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (Skp1A and Skp1B ) and p45 (Skp2) [ J ]. Cytogenet Cell Genet, 1996,73 (1-2) :104-107.
  • 5Jordan R, Bradley G, Slinyerland J. Reduced levels of the cell-cycle inhibitor p27 Kipl in epithelial dysplasia and carcinoma of the oral cavity[J]. Am J Pathol, 1998,142(2) :585-590.
  • 6Garrano AC, Eytan E, Hershko A, et al. SKP2 is required for ubiquitinmediated degradation of the CDK inhibitor p27 [ J]. Nat Cell Biol,1999, 1(4) : 193-199.
  • 7Ganoth D, Bomstein G, Ko TK, et al. The cell-cycle regulatory protein CKS1 is requied for SCF( Skp2 )-mediated ublqultinylation of p27 [J ].Nat Cell Biol,2001,3(3) :321-324.
  • 8Nakayama K, Nagahama H, Minamishima YA, et al, Targeted disruption of Skp2 results in accumulation and centrosome overduplication [ J ].EMBO J,2000,19(9) :2069-2081.
  • 9Ganiatsaa S, Dow R, Thompson A, et al. A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyelin D1 ubiquitination in the uterine cancer cell line SK-UT[J]. Oncogene,2001,20(28) :3641-3650.
  • 10Latres E, Chiarle R, Schulman BA, et al. Role of the F-box protein Skp2 in lymphomagenesis[J] .Proc Natl Acad Sci USA,2001,98(5):2515-2520.

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医学综述
2006年 第6期

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