肿瘤坏死因子-α与糖尿病肾病研究评析

Comment on Studies of Relationship Between Tumor Necrosis Factor Alpha and Diabetic Nephropathy

糖尿病肾病(DN)状态下,血尿肿瘤坏死因子α(TNF-α)水平升高,提示TNF-α参与DN发病。一方面,长期或间歇性高血糖及非酶糖基化终末产物生成增加,促进TNF-α合成与分泌增加;另一方面,TNF-α与其他因素一起,参与DN的发生与发展。血尿TNF-α浓度作为观察DN病情活动的一项有意义指标或血糖控制好坏的佐证之一,有待于进一步定量化、标准化。

The level of TNF-α is high in the blood of NS showed that TNF-α participated in the genesis of NS. On the one hand, longterm or intermittent hyperglycemia and high advanced glycation end products（AGEs） can promote the synthesis and excretion of TNF-α,On the other hand,TNF-α,joined other factors, participates in the formation and development of DN. As one of evidence to control hyperglycemia or one valuable observing index to pathogenetic condition of DN, the level of TNF-α in blood and urine of D1N need to be more quantified and standardized.