高脂血症合并冠心病心绞痛患者血液高凝状态的观察

The Observation on Hypercoagulable State of Patients with Coronary Heart Disease and Hyperlipemia

目的观察高脂血症合并冠心病心绞痛患者凝血及纤溶系统的改变与血栓形成的关系。方法分别采用双抗体夹心法和高效液相法对28例稳定型心绞痛(SAP)、24例不稳定型心绞痛(UAP)、28例高脂血症、22例高脂血症+SAP,21例高脂血症+UAP患者及20例健康人的血浆血管性假性血友病因子相关抗原(vWF:Ag)、血小板α-颗粒膜蛋白(GMP)-140、D-二聚体(D- Dimer)水平以及尿纤维蛋白肽A(UFPA)进行了检测。结果不同类型的心绞痛、高脂血症及高脂血症+SAP和高脂血症+UAP患者上述指标均发生不同程度的改变,与对照组比较大部分指标存在显著差异。结论心绞痛和高脂血症及高脂血症+SAP和高脂血症+UAP患者体内均有不同程度的血栓形成倾向。

Objective To explore the relations and mechanisms on hypercoagulathle state of patients with coronary heart disease （angina pectofis） and hyperlipemia. Methods The levels of plasma yon Willebrand factor： Ag （vWF：Ag）, GMP-140, D-Dimer were determined by doubleblotin-system ELISA and urine fibefinopepfide A （UFPA） by Ion chromatagraphy in hospitalized patients （ 20 eases of stable angina pectofis （SAP） ; 26 cases of unstable angina peetoris （UAP） ;20 eases of hyperlipemia; 24 cases of hyperlipemia ＋ SAP;21 cases of hyperlipemia ＋ UAP） and 20 norreal subjects. Results The result showed that there were significant changes in the patients compared with normal subjects （ P 〈 0.05）. Condusion The results seggeste that coronary heart disease （angina pectofis） and hyperlipemia might have a same pathogenesis of hypercoagulathle state.