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MUC4和ErbB2在胰腺癌中的表达及临床意义 被引量：2

Expression and Clinical Significance of MUC4 and ErbB2 in Pancreatic Cancer
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摘要 目的 探讨MUC4和ErhB2在胰腺癌中的表达及临床意义。方法 免疫组化SP法检测60例胰腺癌．12例慢性胰腺炎及8例正常胰腺组织标本中MUC4和ErbB2蛋白的表达。结果 MUC4和ErbB2在胰腺癌中的表达率较慢性胰腺炎及正常胰腺组织均明显升高（P＜0．01）；ErbB2随胰腺癌病理分化程度的降低．阳性表达率逐渐增高（P〈0．05）；MUC4和ErbB2在临床Ⅲ～Ⅳ期胰腺癌中的表达率均明显高于Ⅰ～Ⅱ期（P〈0．05），在伴淋巴结转移的39例胰腺癌患者中的表达率亦较无淋巴结转移者明显升高（P＜0.05或P＜0.01）。结论 MUC4可能是一个特异的胰腺癌肿瘤相关标志物．与ErbB2共同在胰腺癌的发生、发展中发挥重要作用。 Objective To investigate thc expression and clinical significance of MUC4 and ErbB2 in pancreatic cancer. Methods The expression of MUC4 and ErbB2 was detected by immunohistochemistory of SP in 60 cases of pancreatic cancer. 12 cases of chronic pancreatitis and 8 cases of normat pancreatic tissues. Results The positive rate of the MUC4 and ErbB2 expression was higher in pancreatic cancer than that in chronic pancrealitis and normal pancreas significantly （P〈 0. 01 ）; The positive rate of the ErbB2 expression was increased with the decrease of pathological differentiation in pancreatic cancer （P〈 0.05）; The positive rate of the MUC4 and ErbB2 expression in clinical stagc of Ⅲ-Ⅳ and those with lymph node metastasis were significantly higher than in stage of Ⅰ - Ⅱand those without tymph node metastasis （P〈0.05 or P〈0.01）. Conclusion MUC4 might be a specific tumor marker of pancreatic cancer, and played an important rote in the occurrence and development of pancreatic cancer with ErbB2.
作者 熊炯炘 李晓辉 杨智勇 刘涛 韩保卫 田元 王春友
机构地区 华中科技大学同济医学院附属协和医院胰腺外科中心
出处 《华中科技大学学报（医学版）》 CAS CSCD 北大核心 2006年第1期59-62,共4页 Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
关键词 胰腺癌 MUC4蛋白 ErbB2蛋白 pancreatic cancer MUC4 protein E2rbB2 protein
分类号 R735.9 [医药卫生—肿瘤]
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参考文献12

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同被引文献38

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华中科技大学学报（医学版）
2006年 第1期

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