摘要
水滑石(LDHs)是由带正电荷类水镁石层和层间的可交换阴离子组成的阴离子型粘土化合物,由于它的生物适应性,能够以它为主体,以药物为客体,插层组装成超分子结构复合物。抗炎药萘普生采用共沉淀法一步插层进入LDHs,用X射线衍射、红外光谱及热分析方法表征了超分子结构,表明层间距离扩大了,即萘普生已经插层组装成功,并且以单层、垂直作用在层间。萘普生柱撑水滑石的药物释放度在模拟肠液(pH7.4的缓冲液)条件下测定,结果表明萘普生柱撑水滑石释放速度降低,具有缓释作用,说明药物———无机混合物材料能够用作有效的药物传输系统。
Layered double hydroxides (LDHs), or so-called anionic clays, consist of cationic brucite-like layers and exchangeable interlayer anions. Because of their biocompatibility, LDHs can be used as host materials for drug-LDH host-guest supramolecular structures. The anti-inflammatory drug naproxen has been intercalated into layered double hydroxides by co-precipitation. The product has been characterized by powder X-ray diffraction (XRD), FT-IR spectroscopy, thermal analysis (TG and DTA ) and shows an expanded LDH structure, indicating that the drug has been successfully intercalated into LDH and were orientated perpendicularly between layers by monolayer. Drug release characteristics of the pillared LDH materials were investigated by a dissolution test in a simulated intestinal fluid (buffer at pH 7.4). The results show that the drug release of supramolecular LDH materials was a slow process, suggesting that these drug-inorganic hybrid materials can be used as an effective drug delivery system.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2006年第3期415-417,共3页
Journal of Functional Materials
基金
国家自然科学基金资助项目(20376085)
湖南省教育厅资助项目(05C053)
关键词
水滑石
萘普生
插层
缓释
layered double hydroxides (LDHs)
naproxen
intercalation
controlled release