己酮可可碱对原发性肾病综合征疗效的影响

Effect of pentoxifylline on nephrotic syndrome

目的观察己酮可可碱治疗肾病综合征的疗效。方法采用随机对照法将84例肾病综合征患者分为对照组和治疗组,观察用常规激素治疗与加用己酮可可碱治疗的疗效差异,并进行对照。结果治疗组在降低血肌酐、减少24小时尿蛋白定量、提高血浆白蛋白水平方面均有明显统计学意义。结论在肾病综合征常规治疗基础上加用己酮可可碱能明显促使各项指标的好转,提高疗效,缩短病程,改善肾病综合征的临床预后。

Objective To investigate the effects of pentoxifylline on nephrotie syndrome. Methods 84 patients with nephrotic syndrome were randomly divided into pentoxifylline-treated group and control group. Patients in control group received routine steroids, while those in pentoxifylline-treated group were treated with routine steroids and pentoxifylline. A series of experimental markers were observed before and 3 weeks after the trial. Results As compared with the control group, the proteinuria was significantly decreased and serum albumin significantly increased in the pentoxifylline-treated group. Conclusion Pentoxifylline, being proved to improve efficacy, shorten therapeutic course, and meliorate prognosis, may be an effective adjunct to steroids in treatment of patients with nephrotic syndrome.