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关于B族I型清道夫受体研究进展的认识 被引量：1

Realization of the Researching Progression of the Scavenger Receptor BI
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摘要 B族I型清道夫受体(SR-BI)具有经典的清道夫受体功能,且是HDL的高亲和力受体,并能介导HDL中胆固醇的选择性摄取、影响血浆HDL-C水平以及介导非酯化胆固醇在脂蛋白和细胞之间的双向运动,具有抗动脉粥样硬化的作用。其研究过程反映了相对真理与绝对真理、现象与本质的辩证关系。当新现象被逐一发现,相对真理就逐渐确立,而循序渐进并运用创造性思维,最终将揭示事物的本质,实现相对真理向绝对真理的转化。 Scavenger receptor BI （SR- BI） functions not only as a classic scavenger receptor, but also as a HDL high affinity receptor. It binds I-IDL, facilitates selective HDL cholesterol easter uptake and metabolism, stimulates the bidirectional flux of free cholesterol between cultured cells and lipoproteins, and protects against atherusclerosis. The paper discussed its studying progress by using truth method.
作者 谢湘竹 赵水平 贺达仁
机构地区 中南大学湘雅二医院心血管内科 中南大学哲学系
出处 《医学与哲学（B）》 2006年第2期55-57,共3页 Medicine & Philosophy(B)
关键词 B族Ⅰ型清道夫受体(SR-BI) 高密度脂蛋白(HDL) 动脉粥样硬化 scavenger receptor BI （SR- BI） high density liporotein （HDL） atherosclerosis
分类号 R-02 [医药卫生]
  • 相关文献

参考文献7

  • 1LIUB,KRIEGERM.HighlypurifiedscavengerreceptorclassB,type Ireconstitutedintophosphatidylcholine/cholesterolliposomesmediates highaffinityhighdensitylipoproteinbindingandselectivelipiduptake[].Journal of Biochemistry.2002
  • 2BRAUNA,ZHANGS,MIETTINENHE,etal.Probucolprevents earlycoronaryheartdiseaseanddeathintheHDLreceptorSR-BI/apolipoproteinEdoubleknockoutmouse[].ProcNatlAcadSciUS A.2003
  • 3RIGOTTIA,MIETTINENH,KRIEGERM.Theroleofthehigh densitylipoproteinreceptorSR-BIinthelipidmetabolismofen docrineandothertissues[].Endocrine Reviews.2003
  • 4ACTONS,RIGOTTIA,LANDSCHULZKT,etal.Identificationof scavengerreceptorSR-BIasahighdensitylipoproteinreceptor[].Science.1996
  • 5NIELANDTJ,PENMANM,DORIL,etal.Discoveryofchemical inhibitorsoftheselectivetransferoflipidsmediatedbytheHDLrecep torSR-BI[].Proceedings of the National Academy of Sciences of the United States of America.2002
  • 6BRAUNA,TRIGATTIBL,POSTMJ,etal.LossofSR-BIex pressionleadstotheearlyonsetofocclusiveatheroscleroticcoronary arterydisease,spontaneousmyocardialinfarctions,severecardiacdys function,andprematuredeathinapolipoproteinE-deficientmice[].Circulation Research.2002
  • 7MIETTINENHE,RAYBURNH,KRIEGERM.Abnormallipopro teinmetabolisminHDLreceptor(SR-BI)-deficientmiceandre versiblefemaleinfertility[].The Journal of Clinical Investigation.2001

同被引文献26

  • 1谢湘竹,赵水平.动脉粥样硬化研究的新靶点:B族Ⅰ型清道夫受体[J].中国循环杂志,2005,20(6):479-481. 被引量：4
  • 2Jeyakumar SM,Vajreswari A,Giridharan NV.Impact of vitamin A on high-density lipoprotein-cholesterol and scavenger receptor class BI in the obese rat[J].Obesity (Silver Spring),2007,15 (2):322-329.
  • 3Yancey PG,Bortnick AE,Kellner-Weibel G,de la Llera-Moya M,Phillips MC,Rothblat GH.Importance of different pathways of cellular cholesterol efflux[J].Arterioscler Thromb Vasc Biol,2003,23 (5):712-719.
  • 4Parhofer KG.Beyond LDL-cholesterol:HDL-cholesterol as a target for atherosclerosis prevention[J].Exp Clin End Diab,2005,113 (8):414-417.
  • 5Yancey PG,Kawashiri MA,Moore R,Glick JM,Williams DL,Connelly MA,et al.In vivo modulation of HDL phospholipid has opposing effects on SR-BI-and ABCA1-mediated cholesterol efflux[J].J Lipid Res,2004,45 (2):337-346.
  • 6Thuahnai ST,Lund-Katz S,Dhanasekaran P,de la Llera-Moya M,Connelly MA,Williams DL,et al.Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol.Influence of high density lipoprotein size and structure[J].J Biol Chem,2004,279 (13):12 448-455.
  • 7Temel RE,Walzem RL,Banka CL,Williams DL.Apolipoprotein A-I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI-mediated cholesteryl ester-selective uptake[J].J Biol Chem,2002,277 (29):26 565-572.
  • 8Out R,Hoekstra M,Spijkers JA,Kruijt JK,van Eck M,Bos IS,et al.Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice[J].J Lipid Res,2004,45 (11):2 088-095.
  • 9Huard K,Bourgeois P,Rhainds D,Falstrault L,Cohn JS,Brissette L.Apolipoproteins C-Ⅱ and C-Ⅲ inhibit selective uptake of low-and high-density lipoprotein cholesteryl esters in HepG2 cells[J].J Biol Chem,2005,37 (6):1 308-318.
  • 10Zhang Y,Da Silva JR,Reilly M,Billheimer JT,Rothblat GH,Rader DJ.Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo[J].J Clin Invest,2005,115 (10):2 870-874.

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医学与哲学（B）
2006年 第2期

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