血清乙醇浓度与纳洛酮治疗量的相关性研究

Study of Correlation between Blood Serum Ethanol Chroma and Naloxone Treatment Dose

目的:了解血清乙醇浓度与纳洛酮治疗量之间的相关性。方法:从我院2001年12月1日-2005年8月1日收治的共1991例急性乙醇中毒的病例中随机抽取181例,对这些病例的临床资料进行回顾性分析,了解血清乙醇浓度与纳洛酮治疗量、急性乙醇中毒的临床表现程度与纳洛酮治疗量之间的相关性。结果:变量两两间的相关分析表明:血清乙醇浓度与纳洛酮治疗量之间没有显著性意义的相关性(r=0.045,P>0.05)。而急性乙醇中毒的临床表现程度与纳洛酮治疗量之间有显著性意义的相关性(r=0.3,P<0.01)。结论:急性乙醇中毒的纳洛酮治疗剂量与中毒的临床表现程度有直接的相关性,而与血清乙醇浓度的相关性不显著。

Objective： To study the correlation between blood serum ethanol chroma （BSEC） and naloxone treatment dose （NTD）. Methods： 1991 patients who were from 1st, Dec, 2001 to 1st, Aug, 2005 in our hospital had been randomized among whom clinical data of 181 cases were retrospectively analysed to study the correlation between BSEC and NTD, the degree of clinical behavior of acute ethanol toxication （AET） and NTD. Results： The twain variable relativity analysis showed that the BSEC and NTD was not significantly correlative （r = 0.064, P 〉 0.05）, but the degree of clinical behavior of AET and the NTD was significantly correlative （r = 0.3, P 〈 0.001）. Conclusion： NTD of AET was mainly correlated with its degree of clinical behavior, however, was not significantly correlative with BSEC.