白细胞介素4对几种肿瘤细胞系的生物调节作用

Effect of IL-4 on Biological Regulation of Tumor Cell Lines

采用人重组白细胞介素４（ＩＬ－４）观察了对瘤细胞系的生物调节作用，包括对细胞增殖、分化、表面标志表达及细胞因子分泌的影响。９株不同类型的瘤细胞系对ＩＬ－４的增殖反应不同，即４／９抑制，３／９促进，２／９无影响。ＩＬ－４抑制Ｕ９３７的增殖与其促进细胞分化作用有关。对某些细胞系，ＩＬ－４能增强ＭＨＣＩ类、Ⅱ类及肿瘤相关抗原的表达。ＩＬ－４尚能抑制ＭＬＡ１４４的ＩＬ－２分泌。初步结果表明，ＩＬ－４对瘤细胞有多种生物功能，其调节作用因瘤细胞类型及功能状态的不同而异。

The effect of IL-4 on biological regulation of tumor cell lines was observed by using hu-man recombinant interleukin-4.The observation included cell proliferation, differentiation,cell surface marker and cytokine secretion. The effect of IL-4 on cell proliferation of nine celllines was different.It showed 4/9 inhibitory effect,3/9 enhancing effect and 2/9 no effect.The inhibitory effect of IL-4 on U937 cell proliferation was correlated with cell differentia-tion.IL-4 enhanced the expression of cell surface markers(including MHC class I, MHCclass Ⅱ and TAA)of some cell lines. Furthermore,IL-4 inhibited the production of IL-2 byMLA144.The preliminary results indicate that the effect of IL-4 on biological regulation oftumor cell lines is benefitial for controlling tumor cell growth and enhancing tumor cellrecognition by effector cells,However,the down regulation also could be exerted.