司丙红霉素安全性药理学研究

The safety evaluation of erythromycin stinoprate

目的:观察司丙红霉素对大鼠心血管、呼吸系统和小鼠中枢神经系统的影响。方法:健康SD大鼠分别按体重随机分为低、中、高3个剂量组和溶媒对照组。给药组分别从十二脂肠给予司丙红霉素75,150,300 mg·kg^(-1),对血压、心电图(ECG)、呼吸频率及呼吸幅度进行观察。小鼠实验分低、中、高3个剂量组及溶媒对照共4个组,分别灌胃给予司丙红霉素75,150,300 mg·kg^(-1),对动物一般活动和睡眠时间进行观察。结果:司丙红霉素300 mg·kg^(-1)剂量组使大鼠心率下降,对舒张压、收缩压、ECG之QRS时间、ST段、T波、QT间期、呼吸频率及呼吸幅度无明显的影响;对小鼠一般活动和睡眠时间无明显影响。75,150 mg·kg^(-1)剂量组对大鼠、小鼠各项指标无明显影响。结论:司丙红霉素300 mg·kg^(-1)对心血管系统有一定影响,可使大鼠心率下降。

Objective： To assess the toxicity of erythromycin stinoprate in cardiovascular, respiratory and nervous system in rats and mice. Methods： Healthy SD rats were randomized to administer either erythromycin stinoprate 0, 75, 150 or 300 mg· kg^- 1 by duodenum. The blood pressure, ECG, breath rates and intensity were monitored. Additional mice were randomly administered with one of four oral doses of erythromycin stinoprate 0, 75, 150 or 300 mg· kg^-1. The general activities and sleeping period were monitored. Results： Only erythromycin stinoprate 300 mg· kg^-1 was found to reduce the heart rate of rats, and not to have significant effects on the blood pressure, ECG and breath rate and intensity. No significant effects on the general activity and sleeping period of mice were found. Conclusion ： Erythromycin stinoprate 300 mg· kg^ -1 was significantly toxic on the cardiovascular system of rats.