高同型半胱氨酸血症与肺血栓栓塞症的关联及叶酸干预的价值

The relation between hyperhomocysteine and pulmonary thromboembolism and the effects of folic acid on the levels

目的:探讨高同型半胱氨酸血症(hyperhomocysteine,HHcy)是否增加国人肺血栓栓塞症(PTE)的危险,及叶酸干预对PTE患者HHcy的价值。方法:对41例PTE患者应用高效液相色谱法测定血浆同型半胱氨酸(homocysteine,Hcy)水平,设性别、年龄匹配的正常对照34例。HHcy者给予叶酸、维生素B12,10d后复测血浆Hcy。结果:PTE患者血浆Hcy水平明显高于正常对照组[(20.1±7.8)μmol/L和(13.84±4.7)μmol/L,t=4.79,P<0.05)],HHcy使PTE发生的相对危险增加2.44倍,应用叶酸、维生素B12后血浆Hcy水平显著下降。结论:HHcy是国人PTE的独立危险因素。叶酸、维生素B12能有效降低其血浆Hcy水平。

Objeclive： To investigate whether hyperhomocysteine （HHcy）increases the risk of pulmonary thromboembolism（PTE）, and folio acid reduces HHcy in the disease in the Chinese population. Method：41 patients with PIE and 34 sex and age-matched healthy control were recruited,the patients conformed to the diagnostic criteria formulated by respiratory disease branch, Chinese medicine association. The concentration of plasma Hey was measured with high performance liquid chromatography. The patients with HHcy were treated with 5 mg of folic acid combined with 0.5 mg of vitamine B12 for 10 days. Result： The concentration of plasma Hey in file group was significantly higher than that in healthy control group [ （20.1 ± 7.8 ） ttmol/L vs （ 13.8±4.7 ） μmol/L, t = 4.79, P 〈 0.05 ） ]. Compared with normal plasma Hey, HHcy was associated with a 2.44-fold risk of PTE. Folic acid in combination with vitamine B12 would obviously decrease HHcy. Conclusion：Our results show that HHcy is an independent risk factor of PTE, and folic acid plus vitamine B12 can effectively reduce HHcy in FIE in the Chinese population.